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Dana lived in room number 2206 on the 22nd floor. One day, after returning to her place, Dana witnessed several eggs jump off a carton and fry atop her kitchen counter. She also caught a glimpse of the Temple of Gozer and Zuul inside her refrigerator. She left completely frightened and sought the Ghostbusters for help. Peter investigated with the apartment with a Ghost Sniffer but detected nothing.
On the night she had arranged a date with Dr. Peter Venkman to discuss the details of her case, Dana was attacked inside her apartment by Zuul. This time, however, Dana was unable to escape and was possessed and inhabited by the Terror Dog. Peter later arrived at her place to encounter the possessed Dana and discover that she now called herself Zuul, The Gatekeeper and was now seeking The Keymaster. She spoke of the coming of Gozer and led him to her bedroom, attempting to seduce him under the false impression that he was The Keymaster. Peter rebuffed her advances and an angry Dana spoke in a demonic voice before levitating off her bed, growling and snarling monstrously in frustration. Dana was then sedated by Peter, lying unconscious on her bed while Peter headed back to the Firehouse and finally waking up when the storage grid exploded setting all the captured ghosts free.
With full view from her bay windows, the possessed Dana watched with a contented evil grin as the ghosts and supernatural energy filled the skyline; blowing up her windows with a powerful roar as the energy approached her building leaving a path for The Keymaster to find her. After the explosion Dana awaited the successful arrival of The Keymaster, embracing in a passionate kiss before she led him to Gozer's Temple atop the rooftop of her building where they completed the ritual to open the gates for the coming of Gozer. A hidden stairwell was taken by the pair to directly access the roof. The Ghostbusters later accessed this stairwell when they arrived to save the world.
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