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Ghost Abby is an alternate version of Abby Yates from a parallel universe. Here she is a member of the heroic Pulsebusters, who help defend New York from the living. At one point, after being put on Guard duty by the other Pulsebusters, she was captured in a ghost trap by a Ghostbuster, a Pulsebuster's alternative universe counterpart, who then used the Ghost Trap to free one of the humans captured by the Pulsebusters.
- Ghost Abby appears in the side quest Crossing the Streams, where her universe appears as one of the universes accessed by the Rip Keystone (the other being the universe of the original films).
- The concept of Ghost Abby and the Pulsebusters is very similar to the Peoplebusters as seen in the "Flip Side" episode of The Real Ghostbusters.