|Vehicles and/or Gadgets||None|
|Occupation||Ghostbusters H.Q. Receptionist|
Janine was the first person hired to work at the Firehouse. She staffed the phones and kept track of appointments, calls, messages, etc. While initially extremely bored with her job, once the boys picked up more and more clients, she began to complain of being overworked. After Dr. Venkman implied that perhaps she'd find more pleasure in another low-wage job, she took offense but stopped her complaints. When Walter Peck showed up to shut down the storage facility, she tried to stop them, but the Police Captain, along with all of Walter's paperwork, gave her no choice. Before the explosion at the firehouse, she kept watch with Egon Spengler over Louis Tully who was then possessed by Vinz Clortho the Keymaster. During this time, she begins forming an attraction to Egon, which he isn't sure how to deal with. She later expresses concern for him regarding their confrontation with Gozer.
- Along with Louis Tully, Vigo, Stay Puft and Slimer, she has a substitute actor voicing her.
- In the films, Janine Melnitz is portrayed by Annie Potts. In Lego Dimensions, she is voiced by Courtenay Taylor.
- In the 2016 Ghostbusters reboot, Annie Potts makes a cameo appearence as a desk clerk.
- Janine shares the same headpiece with Jay (without his hood), Raymond Stantz, Captain Jack Harkness, Weightlifter, the Tenth Doctor, Marty McFly, Owen Grady, Templeton "Faceman" Peck, Ethan Hunt, Green Arrow, and Chase McCain.